Dr. Lukas Wichmann

Education & Work

  • Since 2020 – Academic Staff at the Institute of Precision Medicine at Furtwangen University
  • 2015 – 2020 – Dr. rer. nat. Biology at the Institute of Animal Physiology, Justus Liebig University Giessen
    • Dissertation: ‘Molecular Physiology of the Delta Subunit of Epithelial Sodium Channels in Xenopus laevis
  • 2010 – 2015 – B. Sc. and M. Sc. Biology, Justus Liebig University Giessen

Research Interests

  • Multiplex Point of Care Diagnostics
  • Mechanisms of Antibiotic Resistance
  • Molecular Physiology of Ion Channels
  • Osmoregulation in Vertebrate Evolution

Publications

Wichmann L, Althaus M. Evolution of epithelial sodium channels: current concepts and hypotheses. Am J Physiol Regul Integr Comp Physiol. 2020 Oct 1;319(4):R387-R400.

Wichmann L, Dulai JS, Marles-Wright J, Maxeiner S, Szczesniak PP, Manzini I, Althaus M. An extracellular acidic cleft confers profound H+-sensitivity to epithelial sodium channels containing the δ-subunit in Xenopus laevis. J Biol Chem. 2019 Aug 16;294(33):12507-12520.

Wichmann L, Vowinkel KS, Perniss A, Manzini I, Althaus M. Incorporation of the δ-subunit into the epithelial sodium channel (ENaC) generates protease-resistant ENaCs in Xenopus laevis. J Biol Chem. 2018 May 4;293(18):6647-6658.

Perniss A, Wolf A, Wichmann L, Schönberger M, Althaus M. Evans Blue is not a suitable inhibitor of the epithelial sodium channel δ-subunit. Biochem Biophys Res Commun. 2015 Oct 23;466(3):468-74.

Agné AM, Baldin JP, Benjamin AR, Orogo-Wenn MC, Wichmann L, Olson KR, Walters DV, Althaus M. Hydrogen sulfide decreases β-adrenergic agonist-stimulated lung liquid clearance by inhibiting ENaC-mediated transepithelial sodium absorption. Am J Physiol Regul Integr Comp Physiol. 2015 Apr 1;308(7):R636-49.

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